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課程名稱 |
生物分子感測原理與應用
Biomolecular Sensing Principles and Applications |
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開課學期 |
104-1 |
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授課對象 |
生物資源暨農學院 生物機電工程學系 |
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授課教師 |
陳林祈 |
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課號 |
BME5423 |
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課程識別碼 |
631 U3340 |
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班次 |
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學分 |
3 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期五2,3,4(9:10~12:10) |
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上課地點 |
知201 |
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備註 |
總人數上限：60人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1041BME5423_BIOSEN |
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課程簡介影片 |
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核心能力關聯 |
本課程尚未建立核心能力關連 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
美國總統在2015國情咨文倡議精準醫學計畫（precision medicine initiatives），再次引領全球生技業關注分子診斷（molecular diagnostics）和個人化醫療（personalized medicine）等研發議題與每年7%成長率的數十億美元市場契機。生物分子感測（biomolecular sensing）在未來精準醫學生技產業發展裡將扮演著核心關鍵與技術支持的重要角色。本課程聚焦於離子、小分子、蛋白質、核酸等生物分子感測原理與應用教學，藉由授課教師自編講義、學習單與課程實例，開啟修課學生對生物分子感測的興趣與賦予相關領域的進階知識。
*本課程歡迎校外同學選修
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課程目標 |
Knowing & Understanding
1. terminologies of biosensor fields
2. common analytes and their biological significances
3. signal transduction modes and detection methods
4. selective and specific molecular recognition
5. immobilization chemistries and sensor fabrication
6. sensing characteristics and performance factors
7. realistic biosensor systems and practical aspects
Able to
1. construct electrochemical and optical biosensors
2. characterize and analyze biosensor performance
3. design a biosensor total solution for a specific analyte
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課程要求 |
1.Homeworks/reports: 30 %
2.期中考: 35 %
3.期末考: 35 % |
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預期每週課後學習時數 |
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Office Hours |
另約時間 |
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指定閱讀 |
Download the handouts (lecture slides in PDF) from NTU Ceiba.
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參考書目 |
1. Bǎnicǎ, “Chemical Sensors and Biosensors: Fundamentals and
Applications”, Wiley (2012)
http://onlinelibrary.wiley.com/book/10.1002/9781118354162;jsessionid=3797202687E
7F5C42747B83877DC694E.f01t04
2. Eggins, “Chemical Sensors and Biosensors”, Wiley (2002)
http://onlinelibrary.wiley.com/book/10.1002/9780470511305
3. Cunningham, “Introduction to Bioanalytical Sensors”, Wiley (1998)
4. Pallàs-Areny & Webster, “Sensors and Signal Conditioning,” 2nd Ed., Wiley
(2001)
5. Webster & Eren, “Measurement, Instrumentation, and Sensors Handbook,” 2nd
Ed., CRC (2014) http://www.crcnetbase.com/isbn/9781439848890
6. Bard & Faulkner, “Electrochemical Methods: Fundamentals and Applications,”
2nd Ed., Wiley (2001)
7. Wang, “Analytical Electrochemistry,” 3rd Ed., Wiley (2006)
8. Skoog, Holler, & Crouch, “Principles of Instrumental Analysis,” 6th Ed.,
Belmont (2007)
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
Homeworks/Student Presentations |
30% |
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2. |
Midterm |
35% |
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3. |
Final |
35% |
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週次 |
日期 |
單元主題 |
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第0週 |
09/11 |
Review of Chem and Biochem Basics |
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第1週 |
9/18 |
Ch.1: Introduction to Biosensing |
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第2週 |
9/25 |
Ch.1: Introduction to Biosensing (Cont'd)
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第3週 |
10/02 |
Ch.2: Analytes and Their Significances
*Student Presentation (I) Title & Schedule Confirmation
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第4週 |
10/09 |
Holiday |
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第5週 |
10/16 |
Student Presentation (I)
*Homework 1 Due |
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第6週 |
10/23 |
Ch.3: Electrochemical Sensing |
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第7週 |
10/30 |
Ch.3: Electrochemical Sensing (Cont'd)
*HW2 to be assigned on Nov. 2 |
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第8週 |
11/06 |
Ch.3: Electrochemical Sensing (Cont'd)
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第9週 |
11/13 |
Midterm Exam
*Homework 2 Due |
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第10週 |
11/20, 11/27, 12/4 |
期中考講解 + Ch.4: Electronic Sensing：Impedance, Resistance and Field Effect |
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第11週 |
11/27, 12/25 |
Ch.5: Optical Sensing I: Absorption Spectroscopy and Surface Plasma Resonance |
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第12週 |
12/18 |
In Class Electrochemical Lab: CV (Yu-Fu), Glucose Sensing (Chia-Hsin) and EIS (Kuan-Cheng)
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第13週 |
12/25 |
Ch.5-2: Fluorescent Biosensing / Due of HW#3 |
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第14週 |
01/01 |
Holiday
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第15週 |
01/08 |
Ch.6: Immobilization and Coupling Chemistry |
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第18週 |
01/15 |
Final Exam
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